Narasimhan, A.; Chinnaiyan, M.; Karundevi, B. Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat. Butt, M.S. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication The antioxidant activity of four derivatives of benzoic acid was systematically compared with the activity of the four homologous derivatives of cinnamic acid. to access the full features of the site or access our. Marzban, L.; Park, K.; Verchere, C.B. ; Kang, G.; Kim, J.S. ; Chen, C.F. The aim of the review is to summarize the potential mechanisms of these compounds for prevention and management of diabetes and its complications. or in a thesis or dissertation provided that the correct acknowledgement is given Insulin-secretagogue activity of. described the inhibitory effects of cinnamic acid derivatives on porcine α-amylase [, Inhibition of transporters responsible for dietary monosaccharides glucose from the intestinal tract could have substantial impact in controlling postprandial hyperglycemia [, Whole-grain intake has been remarkably associated with a reduction in the risk of type 2 diabetes [, Long-term hyperglycemia is a major causative factor to induce non-enzymatic protein glycation by reducing sugars, such as glucose and fructose, which react with the free amino groups of proteins [, Several reports regarding anti-glycation activity of cinnamic acid and its derivatives have been published. ; El-Refaei, M.F. ; Maskevich, A.A.; Drobchenko, E.A. Philippe, J.; Raccah, D. Treating type 2 diabetes: How safe are current therapeutic agents? ; Wei, X.; Qi, F.M. Standards of medical care in diabetes-2011. Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells. ; Jeon, S.M. ; Cheng, J.T. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. ; Yousef, G.; de Mejia, E.G. Scheen, A.J. The couples of compounds differed for the kind of aromatic substitution (p-hydroxy, p-hydroxymethoxy, p-hydroxydimethoxy, dihydroxy). with the reproduced material. Ma, Y.; Kosińska-Cagnazzo, A.; Kerr, W.L. ; Egorov, A.D.; Mozgovaya, M.N. ; Subhan, N.; Hossain, H.; Hossain, M.; Reza, H.M.; Rahman, M.M. Thornalley, P.J. A. C. Fonseca, M. S. Lima, A. F. Sousa, A. J. Silvestre, J. F. J. Coelho and A. C. Serra, CEMMPRE, Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal, CICECO – Aveiro Institute of Materials and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal, Instructions for using Copyright Clearance Center page. ; Horton, J.D. Smith, P.R. ; Koo, S.H. Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. ; Jannot, M.F. Ye, E.Q. ; Boffetta, P.; Greenwood, D.C.; Tonstad, S.; Vatten, L.J. Jain, S.K. Ruan, H.; Dong, L.Q. Caffeic and chlorogenic acids in. Licensee MDPI, Basel, Switzerland. Oxidative damage of DNA induced by methylglyoxal in vitro. Changes in phenolic compounds in garlic (, Bylka, W. E- and Z-p-methoxycinnamic acid from, Kim, S.R. ; Lai, T.Y. If you are not the author of this article and you wish to reproduce material from Koren, S.; Fantus, I.G. SGLT inhibitors in management of diabetes. ; Hamaker, B.R. Johnston, K.; Sharp, P.; Clifford, M.; Morgan, L. Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. During the glycation process, the oxidative degradation of Amadori intermediates generates superoxide anion such as 1,2- and 2,3-enolization of the Schiff’s base causing oxidative damage to protein detected by increasing formation of protein carbonyl and depleting protein thiol group [, Glycated hemoglobin (Amadori products) is also produced from non-enzymatic glycation between glucose and N-terminal amino acids of beta chains of hemoglobin. Giacco, R.; Costabile, G.; Pepa, G.D.; Anniballi, G.; Griffo, E.; Mangione, A.; Cipriano, P.; Viscovo, D.; Clemente, G.; Landberg, R.; et al. Corresponding authors, a In summary, we have shown that cinnamic acid derivatives activated as fluorinated esters or as cyclic imides can be reduced using Johnson Matthey enzymes ENE-105 or *ENE-69. Enhanced replacement method (ERM) was used for variable selection, and multiple linear regression (MLR) was performed to correlate between structural features of molecules and their acetylcholinesterase inhibitory activity. Please enable JavaScript ; Dong, H. Effects of berberine and cinnamic acid on palmitic acid-induced intracellular triglyceride accumulation in NIT-1 pancreatic β cells. Han, H.S. ; Choi, M.S. Gehrmann, W.; Elsner, M.; Lenzen, S. Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells. Separation and characterization of soluble esterified and glycoside-bound phenolic compounds in dry-blanched peanut skins by liquid chromatography-electrospray ionization mass spectrometry. These compounds are hydroxy derivatives of cinnamic acid. There is also one salt. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well … Jin, X.L. It is worth mentioning that these polymers have a wide spectrum of applications, ranging from industrial (e.g. Adisakwattana, S.; Pongsuwan, J.; Wungcharoen, C.; Yibchok-anun, S. In vitro effects of cinnamic acid derivatives on protein tyrosine phosphatase 1B. ; Vivanco, J.M. The statements, opinions and data contained in the journal, © 1996-2021 MDPI (Basel, Switzerland) unless otherwise stated. Liu, I.M. Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated from the Mavolanate-Shikimate biosynthesis pathways in plants. ; Pinto, B.M. "Reproduced from" can be substituted with "Adapted from". Li, W.; Zhao, X.; Sun, X.; Zu, Y.; Liu, Y.; Ge, Y. These phenolic compounds possess potent antioxidant and anti … ; Sultan, M.T. Its biosynthesis involves the action of the enzyme phenylalanine ammonia-lyase (PAL) on phenylalanine. Regulation of glucose metabolism from a liver-centric perspective. Adisakwattana, S.; Sookkongwaree, K.; Roengsumran, S.; Petsom, A.; Ngamrojnavanich, N.; Chavasiri, W.; Deesamer, S.; Yibchok-anun, S. Structure-activity relationships of trans-cinnamic acid derivatives on alpha-glucosidase inhibition. ; Ullah, M.O. Huang, D.W.; Shen, S.C.; Wu, J.S.B. Alam, M.A. Effect of environmental factors on the kinetics of insulin fibril formation: Elucidation of the molecular mechanism. Jairajpuri, D.S. Aceituno-Medina, M.; Mendoza, S.; Rodríguez, B.A. Cinnamic acid and its derivatives (, As they occur widely and abundantly in human diets, several studies have provided evidence of daily consumption of cinnamic acid and its derivatives in worldwide populations. ; Adisakwattana, S. Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity. Vague, P.; Coste, T.C. Ajith, T.A. ; Volova, E.A. The structure was confirmed by MS and 1H NMR. Cinnamic acid (CA) and its hydroxy-derivatives are aromatic building blocks whose structural peculiarities (unsaturation, hydroxylic and/or carboxylic groups) have driven them to a prominent position in polymer science. Evaluation of antioxidant ability in vitro and bioavailability of trans-cinnamic acid nanoparticle by liquid antisolvent precipitate. Res. ; Vimalambike, M.G. Oral hypoglycemic agents: Insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers. The aim of the review is to summarize the potential mechanisms of these compounds for prevention and management of diabetes and its complications. ; Chen, W.C.; Cheng, J.T. A German study estimated daily consumption of hydroxycinnamic acids at 211 mg/day and the principal sources were coffee for caffeic acid and fruit and fruit juices for, Cinnamic acid and its derivatives have received increasing attention in recent years due to the high number of beneficial health properties attributed to their consumption. 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