Just remember that there is no 100% safe drug use. Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. Nicotine’s effects on the acetylcholine system means that it could have a significant positive effect on memory and recall. I feel very clear-headed on memantine. Ive had minimal unwanted physical side effects. I'd figured they would've found cough medicines that work just as well w/o being psychoactive during the War on Drugs but nah lol. It's clean feeling, compared to DXM. Memantine is voltage-dependent antagonist of nicotinic receptor. Ketamine: Much less sedating. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. Can you elaborate more on how it helped your depression? Take care and go up slowly on the memantine. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. Looks like you're using new Reddit on an old browser. It has a very long half life, and is used medically in doses from 5-10mg(+). D-145; DRG-0267; Pharmacology Indication. 1010111okay on reddit.com Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. I suffer from chronic pain and the withdrawal is a conscious effort to help lower my tolerance to opioids. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. I always use Nicotine with my Opioids, and never just take one or the other. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. It is produced as a hydrochloride salt in its powdered form. Super Sour Ketamine is what I would describe the taste as. New comments cannot be posted and votes cannot be cast. I have ADHD, best described as the Ring of Fire subtype if you buy into the Amen Clinics categorizations. The physical euphoria is apparent, dissociation is only mild, and its still quite easy to stay focused and motivated. Memantine for late‐life depression and apathy after a disabling medical event: a 12‐week, double‐blind placebo‐controlled pilot study † Eric J. Lenze Department of Psychiatry, Washington University, St. … Does it have any effects on the nicotinic receptors? The first week I was trialing it, I remember comparing the effects to that of Valium to my doctor and he seemed surprised by how well it was working. Make sure you follow the RULES. Good, comprehensive guide/advice. I'll explain how some of these play a role in the subjective experience down further. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Mine does shortly up to the point I'm about to make as well, so no judgment. From experience, sublingual seems to have the fastest onset, and reasonable bioavailability, but the taste is rather unpleasant. Memantine also is a Dopamine D2 agonist, a non-competitive Serotonin 5-HT3 antagonist, a non-competitive nAChRs antagonist with similar potencies to NMDA antagonism and the Sigma σ1 receptor with potentially negligible activity. With that being said, I don't think memantine would be an enjoyable experience for everyone. In addition to its glutamatergic modulation, memantine also acts as an agonist at the D2 and nicotinic acetylcholinergic receptors (nAChR). As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. I want to bring it to light as the amazing drug it is. That being said, Memantine is a beautiful drug. T… I've never seen a new user format an article so legitimiately in accordance with the rest of the site. Treatment should only be continued if beneficial effects are seen. It still needs a little tidying up which i will get to over the next couple of days but i just wanted to say thank you. Best Nootropics for 2020. It produces an amazing unique physical euphoria, even in low doses, it's very clear headed, and the visuals are somewhat unique, although I cannot compare it to dissociatives other than Ketamine, DXM & Nitrous. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. Memantine and nicotine patch (small part of patch) optimize activation of cholinergic system. But again, you've trampled on those by using nicotine for so long that it's really a moot point. When in doubt, DON'T. OK just ingested 30 mg, we'll see, I don't want a full blown recreational high but I guess 30mg is good because many drugs just get my anxiety worse. Memantine will help relieve you of the hyperexcitation of the the nmda circuit that will go bonkers when you quit taking opiates. How long do the effects last? I am considering using Memantine (at 10mg/day) during a simultaneous Nicotine and Opioid withdrawal. Memantine is used to manage moderate to severe Alzheimer's dementia Label.. A more recent systemic review and meta-analysis 6 indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer's dementia. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Secondary outcomes included cigarette smoking rate and post-quit nicotine deprivation symptoms (e.g., negative affect, withdrawal). Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. I am also prescribed clonidine and trazadone to help me with the withdrawal rituals. i'm not bipolar but always had cyclothymia, adhd & anxiety. Stop using galantamine and call your doctor at once if you have the first signs of any skin rash, no matter how mild.. Figures 2A,B shows the effect of memantine on the estimated 2-back working memory outcomes, respectively in the absence and presence of nicotine. However, due to ketamine's difficultly to find, expense, and potential damage to the bladder, it isn't something I can regularly use. This includes: URLs, markets, PMs, etc. Memantine (Namenda®) is an uncompetitive NMDA receptor antagonist most commonly used in the management of moderate-to-severe Alzheimer’s disease. Tobacco (most likely the nicotine, but I haven't ingested pure nicotine) also changes the subjective experience of Memantine, although only briefly. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. Less introspective. Memantine. check it out. By using our Services or clicking I agree, you agree to our use of cookies. Functional enough to play games like Overwatch and keep up with it without any struggle. When I am in Opioid withdrawal, I cannot tolerate any Nicotine at all, as it greatly agitates my opioid withdrawal. Due to the long half-life of Memantine, it could mean several more days of misery for me if my experiment doesn't pan out. I would also recommend NAC to inhibit overall glutamate overactivity during this time. after unsuccessful treatment from medical professionals, i went on my own trying to find some relief. So that was something. Psychonautwiki founder here, you did an amazing job on the mementine article dude. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. Thanks again dude. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. Not using is always safer. Mild potentiaition occurs but otherwise I haven't found a way to describe exactly what changes, it is a fairly unique experience. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. Auditory effects are negligible on Memantine, an enhanced appreciation for music is apparent, but no more than a slight ringing in the ears will be noticed (Memantine has shown efficacy in treatment for tinnitus so who knows what's going on there). Great write up, thanks for the info! Press question mark to learn the rest of the keyboard shortcuts. In high doses I found memantine to be a somewhat generic dissociative although it did have some psychedelic style visuals which was a little unusual. Dichloropane is structurally similar to cocaine, atropine and hyoscine, as it contains a tropane ring. I'm not sure on what specific details your looking for but I can answer in more detail whatever questions you ask. YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. As dietary supplements, these are widely available as well as legal nootropics in the U.S.A.. You can buy nootropics in stores or online without a prescription. I could see some thereputic use in this because of it's functionality and long half life. It is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and the mammalian brain. Click here to read the full article @ The European respiratory journal But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Structures and voids are very apparent in low light and I would argue go beyond level 4. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. Call your doctor at once if you have: It is taken by mouth. Memantine isn't very long term memory impairing, in comparison to DXM, or even Ketamine, but short term memory does seem to suffer a bit and you can lose trains of thought quite easily at high doses. Although the half life of Memantine in your body is around 80 hours, the subjective effects are somewhere closer between 12-24 hours, and can be reduced with the acidification of your urine, increasing it's excretion rate. Galantamine side effects. TL;DR: Memantine has a high potential for recreational use. We promote harm reduction and fight against the drugs stigma. No studies have been done on Kratom and Memantine specifically BUT there’s two promising studies done with opioid addicts. Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? In humans, memantine is eliminated in a multicompartment model (Merz & Co.) and the contribution of the first phase to drug action is considerably greater than that of the terminal phase (Merz & Co.). Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. Dosing Memantine is simple, but requires some planning and forethought. Thanks! It feels almost like you can will yourself in and out of consciousness at that dose. Visually fairly similar to ketamine, but more controllable. Please comment back on what your experience was like at that dose though. How often do you use Memantine for depression? It's euphoric, mildly stimulating, and very clear headed compared to other dissociatives. Memantine was tapered up to 20 mg and down to 0 mg over 6 days. Agmatine is considered to be a neurotransmitter and neuromodulator. Press question mark to learn the rest of the keyboard shortcuts. Is it possible to hole on? In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. The tropane ring of RTI-11 is substituted with a carbomethoxy group, also found in cocaine. Identification Name Agmatine Accession Number DB08838 Description. Although doses will vary from person to person, I believe most beginner users would do well with 50mg as a starting recreational dose. It has a pretty clear anxiolytic effect on me. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. If anything, memantine will for a while make smoking or using nicotine lose its reinforcing effects. Eventually, this study was ceased and smoking should only be considered when modafinil is prescribed, especially among people with psychiatric conditions that have high comorbidity with nicotine dependence. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. I can't explain much further, simply because I can't remember what happens when I do it. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. I haven't pushed the limits enough to definitively say it exists. 30mg seems to be barely a threshold dose. According to preliminary research, nAChR agonists like nicotine have the potential to enhance spatial working memory in humans. Discussion of nootropics and cognitive enhancers. How much does it help? Cerestat, IC 50 1.7 (−1; +2) μ M, was more potent than memantine, IC 50 5 (−3;+8) μ M, and the effects of both drugs were fully and rapidly reversible. It concluded Memantine is a cough suppressant as well, so take note of how big your bongs are packed because you wont notice how big it is while pulling it. Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA).Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. And if you can get a hold of some, ibudilast is showing great promise for people with addictions due to its unique effect on microglial inflammation. 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